反应详情

4-Amino-1H-pyrazole-3-carboxylic acid (4-fluorophenyl)-amide (500 mg; 2.27 mmol) was dissolved in 5 ml of pyridine, treated with acetic anhydride (240 μl, 2.5 mmol) then stirred at room temperature overnight. The solvent was removed by evaporation then dichloromethane (20 ml) and 2M hydrochloric acid (20 ml) were added. The undissolved solid was collected by filtration, washed with more dichloromethane and water then dried under vacuum. The product was isolated as an off white solid (275 mg). (LC/MS: Rt 2.96, [M+H]+ 262.91).

1. customThe solvent was removed by evaporation
2. additiondichloromethane (20 ml) and 2M hydrochloric acid (20 ml) were added
3. filtrationThe undissolved solid was collected by filtration
4. washwashed with more dichloromethane and water
5. customthen dried under vacuum