Acetic Anhydride → HCID 178474373, 화합물

HRID 20287노트

반응식

HRID 20287 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[C:15]([NH2:16])=[CH:14][NH:13][N:12]=2)=[O:10])=[CH:4][CH:3]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>N1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[C:15]([NH:16][C:17](=[O:19])[CH3:18])=[CH:14][NH:13][N:12]=2)=[O:10])=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 178508056HCID 178508056, 화합물

생성물 1

HCID 178474373HCID 178474373, 화합물수율 46.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-Amino-1H-pyrazole-3-carboxylic acid (4-fluorophenyl)-amide (500 mg; 2.27 mmol) was dissolved in 5 ml of pyridine, treated with acetic anhydride (240 μl, 2.5 mmol) then stirred at room temperature overnight. The solvent was removed by evaporation then dichloromethane (20 ml) and 2M hydrochloric acid (20 ml) were added. The undissolved solid was collected by filtration, washed with more dichloromethane and water then dried under vacuum. The product was isolated as an off white solid (275 mg). (LC/MS: Rt 2.96, [M+H]+ 262.91).

후처리

  1. customThe solvent was removed by evaporation
  2. additiondichloromethane (20 ml) and 2M hydrochloric acid (20 ml) were added
  3. filtrationThe undissolved solid was collected by filtration
  4. washwashed with more dichloromethane and water
  5. customthen dried under vacuum

출처 및 근거

ORD 기록
ord-b96fd1ce93c541fcb50081990ccad2a1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745638B2

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