Benzylamine → (3R,4R)-4-Amino-1-(methylsulfonyl)piperidin-3-ol
Reaction equation
[BH4-].[Na+].[NH2:1]Cc1ccccc1.[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C:9](=O)[CH2:8][CH2:7]1)(=[O:5])=[O:4]>>[CH3:2][S:3]([N:6]1[CH2:12][C@@H:10]([OH:11])[C@H:9]([NH2:1])[CH2:8][CH2:7]1)(=[O:5])=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Sources & evidence
- ORD record
- ord-512eabb5be45418e918a31909b236a44
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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