Dichloromethane → 3-Chloro-2-(3,3-difluorocyclobutyl)pyridine

HRID 202903Notes

Reaction equation

HRID 202903 reaction equation
[Cl:1][c:2]1[c:3]([C:8]2([C:14]([O:15][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:20])[CH2:9][C:10]([F:12])([F:13])[CH2:11]2)[n:4][cH:5][cH:6][cH:7]1.[Cl:28][CH2:29][Cl:30].[F:21][C:22]([F:23])([F:24])[C:25]([OH:26])=[O:27]>>[Cl:1][c:2]1[c:3]([CH:8]2[CH2:9][C:10]([F:12])([F:13])[CH2:11]2)[n:4][cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58042374Tert-butyl 1-(3-chloropyridin-2-yl)-3,3-difluorocyclobutanecarboxylate

Product 1

HCID 580424303-Chloro-2-(3,3-difluorocyclobutyl)pyridine

Sources & evidence

ORD record
ord-fbbaaff4543a4efbb809b51f97f16a49
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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