Ammonia → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029083Notes

Reaction equation

HRID 2029083 reaction equation
C[C@@H]1[C@H](C(C)(C)[C@@H]2C[C@H]1B([C@H]3[C@H](C)[C@H](C(C)(C)[C@@H]4C3)C4)Cl)C2.[NH3:1].[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C:9](=O)[CH2:8][CH2:7]1)(=[O:5])=[O:4]>>[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C@H:9]([NH2:1])[CH2:8][CH2:7]1)(=[O:5])=[O:4]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 11131038Chlorobis((1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)boraneHCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 1

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-833667d14c86450899b9a8979db6f12a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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