Benzylamine → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029115Notes

Reaction equation

HRID 2029115 reaction equation
CB1N([C@@H]2C(c3ccccc3)(c4ccccc4)O1)CCC2.[NH2:1]Cc1ccccc1.[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C:9](=O)[CH2:8][CH2:7]1)(=[O:5])=[O:4]>>[CH3:2][S:3]([N:6]1[CH2:12][C@H:10]([OH:11])[C@H:9]([NH2:1])[CH2:8][CH2:7]1)(=[O:5])=[O:4]

Participants

5

Reactant 3

HCID 7504BenzylamineHCID 2734713(3aS)-1-methyl-3,3-diphenyl-hexahydropyrrolo(1,2-c)(1,3,2)oxazaboroleHCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 1

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-3d182080c5f4411ea01aacf2b2039c61
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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