Benzylamine → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029116Notes

Reaction equation

HRID 2029116 reaction equation
[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C:8](=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH2:12]Cc1ccccc1.CB1N([C@@H]2C(c3ccccc3)(c4ccccc4)O1)CCC2>>[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C@H:8]([NH2:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 7504BenzylamineHCID 2734713(3aS)-1-methyl-3,3-diphenyl-hexahydropyrrolo(1,2-c)(1,3,2)oxazaboroleHCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 1

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-e10179ac872b408ebc3a141ebeb49048
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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