Benzylamine → (3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

HRID 2029120Notes

Reaction equation

HRID 2029120 reaction equation
[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C:8](=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH2:12]Cc1ccccc1.C[C@@H]1[C@H](C(C)(C)[C@@H]2C[C@H]1B([C@H]3[C@H](C)[C@H](C(C)(C)[C@@H]4C3)C4)Cl)C2>>[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C@H:8]([NH2:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 7504BenzylamineHCID 11131038Chlorobis((1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)boraneHCID 178504951HCID 178504951, compound

Product 1

HCID 178017013(3S,4R)-4-amino-1-methylsulfonylpiperidin-3-ol

Reagents, catalysts & solvents 1

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-4151e3ffe43d4bb197e9c559ece60a25
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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