Methanol → Mk-8245

HRID 202978Notes

Reaction equation

HRID 202978 reaction equation
[Br:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][CH2:7][N:8]([c:11]3[n:12][o:13][c:14](-[c:16]4[n:17][n:18][n:19]([CH2:21][C:22](=[O:23])[O:24][CH2:25][CH3:26])[n:20]4)[cH:15]3)[CH2:9][CH2:10]2)[cH:27][c:28]([F:31])[cH:29][cH:30]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:39][OH:40].[Na+:33].[OH-:32]>>[Br:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][CH2:7][N:8]([c:11]3[n:12][o:13][c:14](-[c:16]4[n:17][n:18][n:19]([CH2:21][C:22](=[O:23])[OH:24])[n:20]4)[cH:15]3)[CH2:9][CH2:10]2)[cH:27][c:28]([F:31])[cH:29][cH:30]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 53388532Ethyl (5-{3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]isoxazol-5-yl}-2H-tetrazol-2-yl)acetate

Product 1

HCID 24988881Mk-8245

Sources & evidence

ORD record
ord-fe506b9d6f5f482095dcff4b639f7ecf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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