3,5-Dibromo-4-methylpyridine → 5-Bromo-4-methylpyridine-3-carbonitrile

HRID 2030977Notes

Reaction equation

HRID 2030977 reaction equation
[CH3:1][Si]([N:2]([Si](C)(C)C)[Na])(C)C.[CH3:3][c:4]1[c:10](Br)[cH:9][n:8][cH:7][c:5]1[Br:6]>>[CH3:3][c:4]1[c:10]([C:1]#[N:2])[cH:9][n:8][cH:7][c:5]1[Br:6]

Participants

6

Reactant 2

HCID 8193383,5-Dibromo-4-methylpyridineHCID 178504303sodium bis(trimethylsilyl)azanide

Product 1

HCID 70606815-Bromo-4-methylpyridine-3-carbonitrile

Reagents, catalysts & solvents 3

HCID 11714597Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)CatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-2d6854dd3d514c9dbb36d1cf397a50aa
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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