Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2031005Generated: November 1, 2026

3,5-Dibromo-4-methylpyridine → 5-Bromo-4-methylpyridine-3-carbonitrile

https://huagongshe.com/reaction/2031005

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Dibromo-4-methylpyridineHCID 819338—
Reactantsodium bis(trimethylsilyl)azanideHCID 178504303—
CatalystTetrakis(triphenylphosphine)palladiumHCID 11979704—
SolventDimethylacetamideHCID 31374—
Product5-Bromo-4-methylpyridine-3-carbonitrileHCID 7060681—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature120 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-0d22961f4c5c4f6581f069b45c3240f7
Source note39k HTE dataset from Pfizer