Tetrabutylammonium Cyanide → 5-Bromo-4-methylpyridine-3-carbonitrile

HRID 2031008Notes

Reaction equation

HRID 2031008 reaction equation
[CH3:1][c:2]1[c:8](Br)[cH:7][n:6][cH:5][c:3]1[Br:4].CCCC[N+](CCCC)(CCCC)CCCC.[C-:9]#[N:10]>>[CH3:1][c:2]1[c:8]([C:9]#[N:10])[cH:7][n:6][cH:5][c:3]1[Br:4]

Participants

6

Reactant 2

HCID 165872Tetrabutylammonium CyanideHCID 8193383,5-Dibromo-4-methylpyridine

Product 1

HCID 70606815-Bromo-4-methylpyridine-3-carbonitrile

Reagents, catalysts & solvents 3

HCID 11714597Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)CatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-a681f2209c284b1f82d209fc2bc75eeb
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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