Dichloromethane → tert-Butyl 4-[(4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxyquinazolin-7-yloxy)methyl]piperidine-1-carboxylate
Reaction equation
[C:59]([CH3:60])([CH3:61])([CH3:62])[O:63][C:64](=[O:65])[N:66]1[CH2:67][CH2:68][CH:69]([CH2:72][OH:73])[CH2:70][CH2:71]1.[CH2:74]([Cl:75])[Cl:76].[F:15][c:16]1[c:17]2[cH:18][c:19]([CH3:39])[nH:20][c:21]2[cH:22][cH:23][c:24]1[O:25][c:26]1[n:27][cH:28][n:29][c:30]2[cH:31][c:32]([OH:38])[c:33]([O:36][CH3:37])[cH:34][c:35]12.[O:1]=[C:2]([O:3][CH:4]([CH3:5])[CH3:6])[N:7]=[N:8][C:9]([O:10][CH:11]([CH3:12])[CH3:13])=[O:14].[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1>>[F:15][c:16]1[c:17]2[cH:18][c:19]([CH3:39])[nH:20][c:21]2[cH:22][cH:23][c:24]1[O:25][c:26]1[n:27][cH:28][n:29][c:30]2[cH:31][c:32]([O:38][CH2:72][CH:69]3[CH2:68][CH2:67][N:66]([C:64]([O:63][C:59]([CH3:60])([CH3:61])[CH3:62])=[O:65])[CH2:71][CH2:70]3)[c:33]([O:36][CH3:37])[cH:34][c:35]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-0c5f570748334521ae857c3a8a3850a6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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