Ammonia → (3R,4R)-4-Amino-1-(methylsulfonyl)piperidin-3-ol

HRID 2032098Notes

Reaction equation

HRID 2032098 reaction equation
[CH3:1][S:2]([N:5]1[CH2:11][C@H:9]([OH:10])[C:8](=O)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH3:12].C[C@@H]1[C@H](C(C)(C)[C@@H]2C[C@H]1B([C@H]3[C@H](C)[C@H](C(C)(C)[C@@H]4C3)C4)Cl)C2>>[CH3:1][S:2]([N:5]1[CH2:11][C@@H:9]([OH:10])[C@H:8]([NH2:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 11131038Chlorobis((1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)boraneHCID 178504951HCID 178504951, compound

Product 1

HCID 58777604(3R,4R)-4-Amino-1-(methylsulfonyl)piperidin-3-ol

Reagents, catalysts & solvents 1

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-2b6beeb1cd864c02a5046482a7837c36
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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