2,2-Difluoro-1,3-dimethylimidazolidine → HCID 178508376, compound

HRID 2032962Notes

Reaction equation

HRID 2032962 reaction equation
CN1C(F)([F:1])N(C)CC1.[NH2:2][c:3]1[n:8][cH:7][c:6]([c:9]2[c:17]([c:13]3[n:12][c:11]([N:24]4[C@@H:29]([CH2:30]O)[CH2:28][O:27][CH2:26][CH2:25]4)[n:10]2)[CH2:16][CH2:15][N:14]3[CH:18]5[CH2:23][C:20]([F:22])([F:21])[CH2:19]5)[cH:5][n:4]1>>[NH2:2][c:3]1[n:8][cH:7][c:6]([c:9]2[c:17]([c:13]3[n:12][c:11]([N:24]4[C@@H:29]([CH2:30][F:1])[CH2:28][O:27][CH2:26][CH2:25]4)[n:10]2)[CH2:16][CH2:15][N:14]3[CH:18]5[CH2:23][C:20]([F:22])([F:21])[CH2:19]5)[cH:5][n:4]1

Participants

5

Reactant 2

HCID 27791112,2-Difluoro-1,3-dimethylimidazolidineHCID 118444360[(3S)-4-[4-(2-aminopyrimidin-5-yl)-7-(3,3-difluorocyclobutyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-2-yl]morpholin-3-yl]methanol

Product 1

HCID 178508376HCID 178508376, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
25 °C

Sources & evidence

ORD record
ord-c4d1ca3c8bc844f7a63a566f9040620c
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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