Tetrahydrofuran → 4-((6-(3-Fluoro-4-(2-morpholinoethoxy)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline

HRID 203383Notes

Reaction equation

HRID 203383 reaction equation
[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[F:10][c:11]1[c:12]([OH:40])[cH:13][cH:14][c:15](-[c:17]2[cH:18][cH:19][c:20]3[n:21]([n:22]2)[c:23]([CH2:26][O:27][c:28]2[cH:29][cH:30][n:31][c:32]4[cH:33][c:34]([O:38][CH3:39])[cH:35][cH:36][c:37]24)[n:24][n:25]3)[cH:16]1.[O:41]=[C:42]([O:43][CH2:44][CH3:45])[N:46]=[N:47][C:48]([O:49][CH2:50][CH3:51])=[O:52].[OH:1][CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1>>[O:1]([CH2:2][CH2:3][N:4]1[CH2:5][CH2:6][O:7][CH2:8][CH2:9]1)[c:12]1[c:11]([F:10])[cH:16][c:15](-[c:17]2[cH:18][cH:19][c:20]3[n:21]([n:22]2)[c:23]([CH2:26][O:27][c:28]2[cH:29][cH:30][n:31][c:32]4[cH:33][c:34]([O:38][CH3:39])[cH:35][cH:36][c:37]24)[n:24][n:25]3)[cH:14][cH:13]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 611632-MorpholinoethanolHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 135955104HCID 135955104, compound

Product 1

HCID 250651344-((6-(3-Fluoro-4-(2-morpholinoethoxy)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)-7-methoxyquinoline

Sources & evidence

ORD record
ord-e66cc8b124d84be393d0f5afa3150bb5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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