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HRID20340

反应详情

EQUATION

反应方程式

HRID 20340 的结构方程式

REACTANTS

反应物

2
结构：CCCC[N+](CCCC)(CCCC)CCCC.[F-]
HCID2724141

Tetra-n-butylammonium fluoride

C16H36FN

结构：CCO[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO[Si](C)(C)C(C)(C)C)CO1
HCID68562682

未命名化合物

PRODUCTS

生成物

1
结构：CCO[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](CO)CO1
HCID68560702

未命名化合物

收率 92.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Dissolve (2S,5R)-5-(tert-butyldimethylsilanyloxymethyl)-2-ethoxymorpholine-4-carboxylic acid tert-butyl ester (0.39 g, 1.04 mmole) in tetrahydrofuran (3 mL) and add tetrabutylammonium fluoride (2.1 mL, 2.1 mmol, 1.0 M in tetrahydrofuran). Stir 45 minutes at room temperature, concentrate and purify (silica gel chromatography, eluting with 10:90 to 40:60 ethyl acetate:hexanes) to give the desired compound (252 mg, 92%).

WORKUP

后处理

  1. concentrationconcentrate
  2. custompurify
  3. wash(silica gel chromatography, eluting with 10:90 to 40:60 ethyl acetate:hexanes)