HRID20351

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H]1[C@H](OCC(C)(C)C)OC[C@H]([C@@H](OCc2ccccc2)[C@@H](Cc2cccc(OCc3ccccc3)c2)N(Cc2ccccc2)Cc2ccccc2)N1C(=O)OC(C)(C)C

HCID68563692

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：C[C@H]1[C@H](OCC(C)(C)C)OC[C@H]([C@@H](O)[C@@H](N)Cc2cccc(O)c2)N1C(=O)OC(C)(C)C

HCID68561574

未命名化合物

收率 104.2%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID9942167

Palladium hydroxide

H2O2Pd

溶剂HCID6386

tert-Butyl alcohol

C4H10O

PROCEDURE

实验过程

Dissolve 5-(R)-[1-(S)-benzyloxy-3-(3-benzyloxyphenyl)-2-(R)-dibenzylaminopropyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester (1.38 g, 1.70 mmol) in tert-butanol (˜50 mL). Add 20% palladium hydroxide on carbon (4 g) and hydrogenate at 50 psi hydrogen gas at 40° C. for 18 hours. Filter and concentrate to give the desired compound (802 mg).

WORKUP

后处理

filtrationFilter
concentrationconcentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f603027a811c4124b583d7961476ec7f
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745438B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([O:46]CC2C=CC=CC=2)[C@H:15]([N:31](CC2C=CC=CC=2)CC2C=CC=CC=2)[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([O:23]CC3C=CC=CC=3)[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:54][CH2:55][C:56]([CH3:59])([CH3:58])[CH3:57])[C@@H:9]1[CH3:60])=[O:7])([CH3:4])([CH3:3])[CH3:2].[H][H]>C(O)(C)(C)C.[OH-].[OH-].[Pd+2]>[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([OH:46])[C@@H:15]([NH2:31])[CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([OH:23])[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:54][CH2:55][C:56]([CH3:59])([CH3:58])[CH3:57])[C@@H:9]1[CH3:60])=[O:7])([CH3:2])([CH3:4])[CH3:3]