反应详情

5.00 g of 4,6-dichloropyridine-3-carboxyamide synthesized according to the method described in US 2006/0217417 was dissolved in 50 mL of ethanol, to which 3.37 g of benzylamine and 4.40 g of N,N-diisopropylethylamine were added, and heated at reflux for 12 hours. After cooling, the solvent was evaporated, and 100 mL of water was added to the residue. After cooling with ice, the deposited crystals were filtered, washed with water and hexane, and air-dried. It was further dried under reduced pressure (100° C., 2 hours) to obtain the title compound (5.96 g, 87%) as light yellow needle crystals.

1. additionwere added
2. temperatureheated
3. temperatureat reflux for 12 hours
4. temperatureAfter cooling
5. customthe solvent was evaporated
6. addition100 mL of water was added to the residue
7. temperatureAfter cooling with ice
8. filtrationthe deposited crystals were filtered
9. washwashed with water and hexane
10. customair-dried
11. customIt was further dried under reduced pressure (100° C., 2 hours)