HCID 131730940, compound → HCID 131730939, compound

HRID 2035488Notes

Reaction equation

HRID 2035488 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[N:19]=[CH:18][C:17]([CH2:20][C:21]([NH2:23])=[O:22])=[C:16]([NH:24][CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[C:28]([N+:32]([O-])=O)[CH:27]=4)[CH:15]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.[C].[Pd]>[NH2:32][C:28]1[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=1)[CH2:25][NH:24][C:16]1[CH:15]=[C:14]([NH:13][C:10]2[CH:9]=[CH:8][C:7]([N:4]3[CH2:5][CH2:6][O:1][CH2:2][CH2:3]3)=[CH:12][CH:11]=2)[N:19]=[CH:18][C:17]=1[CH2:20][C:21]([NH2:23])=[O:22]

Participants

5

Reactant 2

HCID 131730940HCID 131730940, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131730939HCID 131730939, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 176Acetic AcidSolvent

Procedure

21 mg of 6-[(4-morpholinophenyl)amino]-4-[(3-nitrobenzyl)amino]pyridine-3-carboxyamide (the compound of Example 102) was dissolved in 1 mL of acetic acid, to which 21 mg of 10% palladium carbon was added, and stirred in a hydrogen atmosphere at room temperature for 4 hours. The 10% palladium carbon was filtered off, and the solvent was evaporated to obtain 19.5 mg (100%) of the title compound as a light gray solid.

Workup

  1. additionwas added
  2. filtrationThe 10% palladium carbon was filtered off
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-1e16bace679549d996fef79173f77c64
Source dataset
uspto-grants-2013_11
Patent number
US08575153B2

Reaction notes

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