3,5-Difluorobenzylamine → HCID 58440220, compound

HRID 2035522Notes

Reaction equation

HRID 2035522 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([Cl:13])=[CH:10][C:11]=1Cl)=[O:5])[CH3:2].[F:14][C:15]1[CH:16]=[C:17]([CH:20]=[C:21]([F:23])[CH:22]=1)[CH2:18][NH2:19]>>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([Cl:13])=[CH:10][C:11]=1[NH:19][CH2:18][C:17]1[CH:16]=[C:15]([F:14])[CH:22]=[C:21]([F:23])[CH:20]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 1452113,5-DifluorobenzylamineHCID 600045Ethyl 4,6-dichloropyridine-3-carboxylate

Product 1

HCID 58440220HCID 58440220, compound

Procedure

From 4,6-dichloropyridine-3-carboxylic acid ethylester synthesized according to the method described in US2006/0217417 and 3,5-difluorobenzylamine in a manner similar to Example 1, 6-chloro-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxylic acid ethyl ester was obtained as a light brown crystalline powder (yield 82%).

Sources & evidence

ORD record
ord-f73ced56cdfc49d7b2fd541b6ef7d014
Source dataset
uspto-grants-2013_11
Patent number
US08575153B2

Reaction notes

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