反应详情

tert-Butyl 4-((2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)methyl)-4-methoxyazepane-1-carboxylate (0.040 g, 0.079 mmol) was added to a mixture of trifluoroacetic acid and DCM (1:1) for 30 minutes, and the reaction was concentrated. Ethyl acetate was added and the suspension was filtered through a Waters filter (to remove any errant silica gel), and the filtrate was concentrated. DCM was added followed by precipitation with HCl dissolved in diethyl ether, evaporated, co-evaporated in diethyl ether to yield 16 mgs of the desired product as a yellow solid (95% pure by LC). MS ESI (+) m/z 404 (M+1) detected.

1. concentrationthe reaction was concentrated
2. additionEthyl acetate was added
3. filtrationthe suspension was filtered through a Waters
4. filtrationfilter (
5. customto remove any errant silica gel), and the filtrate
6. concentrationwas concentrated
7. additionDCM was added
8. customfollowed by precipitation with HCl
9. dissolutiondissolved in diethyl ether
10. customevaporated, co-evaporated in diethyl ether