Acetic acid--water (1/1) → HCID 58063556, compound

HRID 2035695Notes

Reaction equation

HRID 2035695 reaction equation
[F:1][C:2]1[C:7]2[CH2:8][CH2:9][CH:10]([N:19]3[CH:23]=[C:22]([C:24]4[CH:29]=[CH:28][N:27]=[C:26](F)[CH:25]=4)[N:21]=[N:20]3)[C:11](=[O:18])[N:12]([CH2:13][C:14]([F:17])([F:16])[F:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1.CC(O)=[O:33].O>>[F:1][C:2]1[C:7]2[CH2:8][CH2:9][CH:10]([N:19]3[CH:23]=[C:22]([C:24]4[CH:29]=[CH:28][NH:27][C:26](=[O:33])[CH:25]=4)[N:21]=[N:20]3)[C:11](=[O:18])[N:12]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21899381Acetic acid--water (1/1)HCID 58063565HCID 58063565, compound

Product 1

HCID 58063556HCID 58063556, compound

Procedure

In a sealed tube, 6-fluoro-3-[4-(2-fluoropyridin-4-yl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (100 mg, 0.236 mmol) in 1.2 mL of 5:1 AcOH/H2O was heated at 120° C. overnight. After cooled to ambient temperature and solvent reduced under reduced pressure, the residue was purified by column chromatography on silica gel (0-20% MeOH in EtOAc) to afford 98 mg title compound.

Workup

  1. customthe residue was purified by column chromatography on silica gel (0-20% MeOH in EtOAc)

Sources & evidence

ORD record
ord-755050736c664051bab8e20503a0dead
Source dataset
uspto-grants-2013_11
Patent number
US08575150B2

Reaction notes

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