Acetic acid--water (1/1) → HCID 58063556, compound

Participants

Reaction Steps

In a sealed tube, 6-fluoro-3-[4-(2-fluoropyridin-4-yl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (100 mg, 0.236 mmol) in 1.2 mL of 5:1 AcOH/H2O was heated at 120° C. overnight. After cooled to ambient temperature and solvent reduced under reduced pressure, the residue was purified by column chromatography on silica gel (0-20% MeOH in EtOAc) to afford 98 mg title compound.

Provenance & Evidence