HCID 66747989, compound → HCID 66748707, compound

HRID 2035779Notes

Reaction equation

HRID 2035779 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:16]2=[N:17][S:18](=[O:22])(=[O:21])[CH2:19][CH2:20][N:15]2[CH:14]=[CH:13][CH:12]=1>C1COCC1.CO.[Pt](=O)=O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]1[C:16]2=[N:17][S:18](=[O:21])(=[O:22])[CH2:19][CH2:20][N:15]2[CH2:14][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 66747989HCID 66747989, compound

Product 1

HCID 66748707HCID 66748707, compoundYield 68.9%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a solution of 9-naphthalen-2-yl-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (150 mg) in THF/methanol (30 mL/30 mL) was added platinum (IV) oxide (50 mg). The reaction mixture was stirred under a hydrogen atmosphere at room temperature for 7 hr, and insoluble material was filtered off through celite. The filtrate was concentrated under reduced pressure, and the obtained residue was purified by recrystallization (methanol-THF/diisopropyl ether) to give the title compound (104.7 mg).

Workup

  1. filtrationinsoluble material was filtered off through celite
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe obtained residue was purified by recrystallization (methanol-THF/diisopropyl ether)

Sources & evidence

ORD record
ord-6cf495b84033452096d0d5c41bad143c
Source dataset
uspto-grants-2013_11
Patent number
US08575154B2

Reaction notes

Loading…