HCID 66748164, compound → HCID 66823919, compound

HRID 2035951Notes

Reaction equation

HRID 2035951 reaction equation
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:16]3=[N:17][S:18](=[O:22])(=[O:21])[CH2:19][CH2:20][N:15]3[CH:14]=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)[CH2:2][CH3:3]>CO.[Pt](=O)=O>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[C:16]3=[N:17][S:18](=[O:21])(=[O:22])[CH2:19][CH2:20][N:15]3[CH2:14][CH2:13][CH2:12]2)=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 66748164HCID 66748164, compound

Product 1

HCID 66823919HCID 66823919, compoundYield 37.5%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

A mixture of 9-(4-propoxyphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide (300 mg) and platinum(IV) oxide (32.1 mg) in MeOH (10 mL) was stirred at room temperature under H2 for 20 hr. The reaction mixture was filtered by Celite and the filtrate was concentrated in vacuo. The residue was recrystallized from EtOAc-MeOH to give the title compound (114 mg) as a white solid.

Workup

  1. filtrationThe reaction mixture was filtered by Celite
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was recrystallized from EtOAc-MeOH

Sources & evidence

ORD record
ord-eac3dafa8dd84ecca5496c209e2e4f5b
Source dataset
uspto-grants-2013_11
Patent number
US08575154B2

Reaction notes

Loading…