HCID 66747936, compound → HCID 66748382, compound

HRID 2035984Notes

Reaction equation

HRID 2035984 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:19]3=[N:20][S:21](=[O:25])(=[O:24])[CH2:22][CH2:23][N:18]3[CH:17]=[CH:16][N:15]=2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCO.[Pt](=O)=O>[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[C:19]3=[N:20][S:21](=[O:25])(=[O:24])[CH2:22][CH2:23][N:18]3[CH2:17][CH2:16][NH:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 66747936HCID 66747936, compound

Product 1

HCID 66748382HCID 66748382, compoundYield 33%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 9-(4-phenoxyphenyl)-3,4-dihydropyrazino[2,1-c][1,2,4]thiadiazine 2,2-dioxide (96.0 mg), and platinum(IV) oxide (15.0 mg) in EtOH (5 ml) was stirred at room temperature for 2.5 hr under H2. The mixture was added with NH silica gel, concentrated, purified by column chromatography (NH silica gel, eluted with MeOH in EtOAc), then recrystallized from EtOAc-IPE to give the title compound (32.0 mg) as white powder.

Workup

  1. additionThe mixture was added with NH silica gel
  2. concentrationconcentrated
  3. custompurified by column chromatography (NH silica gel, eluted with MeOH in EtOAc)
  4. customrecrystallized from EtOAc-IPE

Sources & evidence

ORD record
ord-3e29ac7103344d3a823b05b013a7334c
Source dataset
uspto-grants-2013_11
Patent number
US08575154B2

Reaction notes

Loading…