Potassium Carbonate → 1'-[6-(3-Methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]spiro[indene-1,4'-piperidine]

HRID 2036072Notes

Reaction equation

HRID 2036072 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.FC(F)(F)C(O)=O.[NH:21]1[CH2:26][CH2:25][C:24]2([C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=[CH:27]2)[CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:21]3[CH2:26][CH2:25][C:24]4([C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[CH:28]=[CH:27]4)[CH2:23][CH2:22]3)=[CH:7][CH:6]=2)[S:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazineHCID 67087057Spiro[indene-1,4'-piperidine] trifluoroacetate

Product 1

HCID 685533111'-[6-(3-Methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]spiro[indene-1,4'-piperidine]

Procedure

The object product (22 mg, 25%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (51 mg), spiro[indene-1,4′-piperidine] trifluoroacetate (105 mg) and potassium carbonate (70 mg).

Sources & evidence

ORD record
ord-84d54bcb540149b89ee5e405b761bc10
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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