Potassium Carbonate → HCID 68558840, compound

HRID 2036078Notes

Reaction equation

HRID 2036078 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[NH:15]1[CH2:20][CH2:19][C:18]2([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[CH2:22][O:21]2)[CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:15]3[CH2:20][CH2:19][C:18]4([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=5[CH2:22][O:21]4)[CH2:17][CH2:16]3)=[CH:7][CH:6]=2)[S:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazineHCID 225093303H-spiro(2-benzofuran-1,4'-piperidine) hydrochloride

Product 1

HCID 68558840HCID 68558840, compound

Procedure

The object product (66 mg, 26%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (150 mg), 3H-spiro[2-benzofuran-1,4′-piperidine] hydrochloride (159 mg) and potassium carbonate (244 mg).

Sources & evidence

ORD record
ord-ed374209589745c799f3a0f619a4e356
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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