Potassium Carbonate → 1'-(6-Phenylpyridazin-3-yl)spiro[indene-1,4'-piperidine]

HRID 2036080Notes

Reaction equation

HRID 2036080 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.FC(F)(F)C(O)=O.[NH:21]1[CH2:26][CH2:25][C:24]2([C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=[CH:27]2)[CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+]>>[C:8]1([C:5]2[N:4]=[N:3][C:2]([N:21]3[CH2:26][CH2:25][C:24]4([C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[CH:28]=[CH:27]4)[CH2:23][CH2:22]3)=[CH:7][CH:6]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 885153-Chloro-6-phenylpyridazineHCID 67087057Spiro[indene-1,4'-piperidine] trifluoroacetate

Product 1

HCID 685547321'-(6-Phenylpyridazin-3-yl)spiro[indene-1,4'-piperidine]

Procedure

The object product (54 mg, 27%) was obtained in the same manner as in Example 1 and using 3-chloro-6-phenylpyridazine (114 mg), spiro[indene-1,4′-piperidine] trifluoroacetate (210 mg) and potassium carbonate (130 mg).

Sources & evidence

ORD record
ord-dde63e8f59564434a77809e5d6597c0a
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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