Potassium Carbonate → 1'-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3-yl]spiro[indene-1,4'-piperidine]

HRID 2036083Notes

Reaction equation

HRID 2036083 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1.FC(F)(F)C(O)=O.[NH:22]1[CH2:27][CH2:26][C:25]2([C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH:29]=[CH:28]2)[CH2:24][CH2:23]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:14][C:10]1[CH:11]=[C:12]([CH3:13])[N:8]([C:5]2[N:4]=[N:3][C:2]([N:22]3[CH2:27][CH2:26][C:25]4([C:35]5[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=5)[CH:29]=[CH:28]4)[CH2:24][CH2:23]3)=[CH:7][CH:6]=2)[N:9]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 3210733-Chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazineHCID 67087057Spiro[indene-1,4'-piperidine] trifluoroacetate

Product 1

HCID 685533231'-[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3-yl]spiro[indene-1,4'-piperidine]

Procedure

The object product (67 mg, 19%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (209 mg), spiro[indene-1,4′-piperidine] trifluoroacetate (300 mg) and potassium carbonate (275 mg).

Sources & evidence

ORD record
ord-b9bc69fcc087416ebf148b603089e153
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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