HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzyl alcohol → Tert-butyl 3-hydroxy-3-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzyl alcohol | HCID 72850 | — |
| Reactant | Tert-butyl 3-oxopiperidine-1-carboxylate | HCID 2756825 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | Tert-butyl 3-hydroxy-3-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate | HCID 68557078 | — |
Reaction Steps
The object product (1.6 g, 30%) was obtained in the same manner as in Example 14(1) and using (2-bromophenyl)methanol (3.3 g), tert-butyl 3-oxopiperidine-1-carboxylate (3.5 g) and n-butyllithium (1.6 M hexane solution, 23 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575167B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6ad32376a4764347ac8f5f7e2ecfc827 |
| Source note | uspto-grants-2013_11 |