Potassium Carbonate → 1'-[6-(3-Methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-3,4-dihydrospiro[chromene-2,4'-piperidine]

HRID 2036094Notes

Reaction equation

HRID 2036094 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[NH:15]1[CH2:20][CH2:19][C:18]2([CH2:29][CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[O:21]2)[CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:15]3[CH2:20][CH2:19][C:18]4([CH2:29][CH2:28][C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[O:21]4)[CH2:17][CH2:16]3)=[CH:7][CH:6]=2)[S:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazineHCID 498455023,4-Dihydrospiro[1-benzopyran-2,4'-piperidine] hydrochloride

Product 1

HCID 685558071'-[6-(3-Methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-3,4-dihydrospiro[chromene-2,4'-piperidine]

Procedure

The object product (74 mg, 44%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (95 mg), 3,4-dihydrospiro[chromene-2,4′-piperidine] hydrochloride (105 mg) and potassium carbonate (138 mg).

Sources & evidence

ORD record
ord-4c54a80c4afa4fc39255e1ab02151b64
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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