Potassium Carbonate → HCID 68554356, compound

HRID 2036107Notes

Reaction equation

HRID 2036107 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.[F:14][C:15]1[CH:16]=[C:17]([N:21]2[CH2:25][C:24]3([CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[O:23][C:22]2=[O:31])[CH:18]=[CH:19][CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>>[F:14][C:15]1[CH:16]=[C:17]([N:21]2[CH2:25][C:24]3([CH2:26][CH2:27][N:28]([C:2]4[N:3]=[N:4][C:5]([C:8]5[O:12][N:11]=[C:10]([CH3:13])[N:9]=5)=[CH:6][CH:7]=4)[CH2:29][CH2:30]3)[O:23][C:22]2=[O:31])[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazineHCID 56773862HCID 56773862, compound

Product 1

HCID 68554356HCID 68554356, compound

Procedure

The object product (82 mg, 57%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (70 mg) obtained in Example 43(2), 3-(3-fluorophenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one (80 mg) obtained in Example 29(3) and potassium carbonate (50 mg).

Sources & evidence

ORD record
ord-aa208d8f89e64a65ba149ce233a36ba2
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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