Potassium Carbonate → HCID 68556451, compound

HRID 2036108Notes

Reaction equation

HRID 2036108 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[NH:15]1[CH2:19][CH2:18][C:17]2([CH2:28][C:27](=[O:29])[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[O:20]2)[CH2:16]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:15]3[CH2:19][CH2:18][C:17]4([CH2:28][C:27](=[O:29])[C:26]5[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=5)[O:20]4)[CH2:16]3)=[CH:7][CH:6]=2)[O:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazineHCID 68558595HCID 68558595, compound

Product 1

HCID 68556451HCID 68556451, compound

Procedure

The object product (148 mg, 62%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (130 mg) obtained in Example 43(2), spiro[chromene-2,3′-pyrrolidin]-4(3H)-one hydrochloride (160 mg) obtained in Example 21(2) and potassium carbonate (110 mg).

Sources & evidence

ORD record
ord-a43ed26aaf954925bd2891798d506dfa
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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