Potassium Carbonate → HCID 68555540, compound

HRID 2036117Notes

Reaction equation

HRID 2036117 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.[NH:14]1[CH2:19][CH2:18][C:17]2([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[C:21](=[O:28])[O:20]2)[CH2:16][CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:14]3[CH2:19][CH2:18][C:17]4([C:23]5[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=5[C:21](=[O:28])[O:20]4)[CH2:16][CH2:15]3)=[CH:7][CH:6]=2)[O:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 98342553H-spiro(isobenzofuran-1,4'-piperidin)-3-oneHCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine

Product 1

HCID 68555540HCID 68555540, compound

Procedure

The object product (187 mg, 52%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (200 mg) obtained in Example 43(2), 3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (240 mg) and potassium carbonate (140 mg).

Sources & evidence

ORD record
ord-0ee0546248594117ac4987222c572788
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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