HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-6-(1H-imidazol-1-yl)pyridazine → 1'-[6-(1H-imidazol-1-yl)pyridazin-3-yl]-3H-spiro[2-benzofuran-1,3'-pyrrolidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-6-(1H-imidazol-1-yl)pyridazine | HCID 2770903 | — |
| Reactant | 3H-spiro[2-benzofuran-1,3'-pyrrolidine] hydrochloride | HCID 66662035 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1'-[6-(1H-imidazol-1-yl)pyridazin-3-yl]-3H-spiro[2-benzofuran-1,3'-pyrrolidine] | HCID 68553262 | — |
Reaction Steps
The object product (195 mg, 61%) was obtained in the same manner as in Example 165 and using 3-chloro-6-(1H-imidazol-1-yl)pyridazine (180 mg), 3H-spiro[2-benzofuran-1,3′-pyrrolidine] hydrochloride (200 mg) obtained in Example 43(5) and triethylamine (0.42 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575167B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d579883652a64e258855bde991d36576 |
| Source note | uspto-grants-2013_11 |