3-Chloro-6-(1H-imidazol-1-yl)pyridazine → 1'-[6-(1H-imidazol-1-yl)pyridazin-3-yl]-3H-spiro[2-benzofuran-1,3'-pyrrolidine]

HRID 2036121Notes

Reaction equation

HRID 2036121 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH:12]=[CH:11][N:10]=[CH:9]2)=[CH:6][CH:7]=1.Cl.[NH:14]1[CH2:18][CH2:17][C:16]2([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH2:20][O:19]2)[CH2:15]1>C(N(CC)CC)C>[N:8]1([C:5]2[N:4]=[N:3][C:2]([N:14]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[CH2:20][O:19]4)[CH2:15]3)=[CH:7][CH:6]=2)[CH:12]=[CH:11][N:10]=[CH:9]1

Participants

4

Reactant 2

HCID 27709033-Chloro-6-(1H-imidazol-1-yl)pyridazineHCID 666620353H-spiro[2-benzofuran-1,3'-pyrrolidine] hydrochloride

Product 1

HCID 685532621'-[6-(1H-imidazol-1-yl)pyridazin-3-yl]-3H-spiro[2-benzofuran-1,3'-pyrrolidine]

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The object product (195 mg, 61%) was obtained in the same manner as in Example 165 and using 3-chloro-6-(1H-imidazol-1-yl)pyridazine (180 mg), 3H-spiro[2-benzofuran-1,3′-pyrrolidine] hydrochloride (200 mg) obtained in Example 43(5) and triethylamine (0.42 mL).

Sources & evidence

ORD record
ord-d579883652a64e258855bde991d36576
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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