Potassium Carbonate → HCID 68557530, compound

HRID 2036126Notes

Reaction equation

HRID 2036126 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[CH3:15][N:16]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:18]2([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:17]1=[O:30].C(=O)([O-])[O-].[K+].[K+]>>[CH3:15][N:16]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:18]2([CH2:23][CH2:22][N:21]([C:2]3[N:3]=[N:4][C:5]([C:8]4[O:12][N:11]=[C:10]([CH3:13])[N:9]=4)=[CH:6][CH:7]=3)[CH2:20][CH2:19]2)[C:17]1=[O:30]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazineHCID 68556841HCID 68556841, compound

Product 1

HCID 68557530HCID 68557530, compound

Procedure

The object product (40 mg, 53%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (39 mg) obtained in Example 43(2), 1-methylspiro[indole-3,4′-piperidin]-2(1H)-one hydrochloride (51 mg) and potassium carbonate (55 mg).

Sources & evidence

ORD record
ord-1937e86ef8034df09633134ebd64845c
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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