Potassium Carbonate → 1'-[6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazin-3-yl]spiro[indene-2,4'-piperidin]-1(3H)-one

HRID 2036129Notes

Reaction equation

HRID 2036129 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[NH:15]1[CH2:20][CH2:19][C:18]2([CH2:28][C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]2=[O:29])[CH2:17][CH2:16]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:15]3[CH2:16][CH2:17][C:18]4([CH2:28][C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[C:21]4=[O:29])[CH2:19][CH2:20]3)=[CH:7][CH:6]=2)[O:12][N:11]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 167322943-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazineHCID 68556495Spiro[indene-2,4'-piperidin]-1(3H)-one hydrochloride

Product 1

HCID 685574551'-[6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazin-3-yl]spiro[indene-2,4'-piperidin]-1(3H)-one

Procedure

The object product (173 mg, 76%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (124 mg) obtained in Example 43(2), spiro[indene-2,4′-piperidin]-1(3H)-one hydrochloride (150 mg) and potassium carbonate (174 mg).

Sources & evidence

ORD record
ord-dc07b7891e734f4284b36cbb91f2a084
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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