Formic Acid → HCID 66654229, compound

HRID 2036208Notes

Reaction equation

HRID 2036208 reaction equation
[F-:1].[K+].C([O:5][C:6](=[O:29])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C@@H:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:18][N:17]1[C:25](=[O:28])[CH:26]=[CH2:27])C.F[C:31]1[CH:32]=[C:33]2[C:37](=[CH:38][CH:39]=1)[NH:36][N:35]=[CH:34]2.C(O)=O>CC#N>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:29])=[C:10]([CH:16]2[C:24]3[C:19](=[CH:20][C:21]([F:1])=[CH:22][CH:23]=3)[CH2:18][N:17]2[C:25](=[O:28])[CH2:26][CH2:27][N:36]2[C:37]3[C:33](=[CH:32][CH:31]=[CH:39][CH:38]=3)[CH:34]=[N:35]2)[CH:11]=1

Participants

6

Reactant 4

HCID 284Formic AcidHCID 522689Potassium FluorideHCID 178424865-Fluoro-1H-indazoleHCID 66654307HCID 66654307, compound

Product 1

HCID 66654229HCID 66654229, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

Potassium fluoride 40 wt. % on alumina (218 mg, 3.75 mmol, 25 eq.) was added to a mixture of [2-((S)-2-acryloyl-2,3-dihydro-1H-isoindol-1-yl)-4-chloro-phenoxy]-acetic acid ethyl ester (58 mg, 0.15 mmol, 1.0 eq.) and 5-fluoro-1H-indazole (25 mg, 0.18 mmol, 1.2 eq.) in MeCN (1 mL). The resulting suspension was stirred at 80° C. for 18 hours. Formic acid was added (0.2 mL). The reaction mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by prep. HPLC (column: Atlantis, 30×75 mm, 10 um, UV/MS, acidic conditions) and concentrated in vacuo to give the desired product as a white foam.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe residue was purified by prep
  4. concentrationHPLC (column: Atlantis, 30×75 mm, 10 um, UV/MS, acidic conditions) and concentrated in vacuo

Sources & evidence

ORD record
ord-a6fc6d8d04514e9aa7166365c8696fc8
Source dataset
uspto-grants-2013_11
Patent number
US08575158B2

Reaction notes

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