HCID 67224686, compound → 2-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-2-ylmethyl)amino]propyl}-9H-purin-6-amine

HRID 2036346Notes

Reaction equation

HRID 2036346 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24][CH3:25])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][C@@H:19]2[CH2:23][CH2:22][CH2:21]O2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].F[C:28](F)(F)[C:29](O)=[O:30].C(OC1NC(N)=C2C(N=1)=NC(OC)=N2)CCC>>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24][CH3:25])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:23]2[CH2:22][CH2:21][CH2:28][CH2:29][O:30]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 67224686HCID 67224686, compoundHCID 178450357HCID 178450357, compound

Product 1

HCID 672113682-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-2-ylmethyl)amino]propyl}-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 14 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and (tetrahydro-2H-pyran)-2-ylmethyl)amine hydrochloride.

Sources & evidence

ORD record
ord-2f51dc03989d4af794e66c8ce148257b
Source dataset
uspto-grants-2013_11
Patent number
US08575181B2

Reaction notes

Loading…