4-Aminomethyltetrahydropyran → 2-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-4-ylmethyl)amino]propyl}-9H-purin-6-amine

HRID 2036350Notes

Reaction equation

HRID 2036350 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23]CO2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4].F[C:29](F)(F)[C:30](O)=[O:31].C(OC1NC(N)=C2C(N=1)=NC(OC)=N2)CCC.O1CCC(CN)CC1>>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23][O:31][CH2:30][CH2:29]2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Procedure

Prepared similarly to Intermediate 15 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and (tetrahydro-2H-pyran-4-ylmethyl)amine.

Sources & evidence

ORD record
ord-6712c22bfbe34b199f4ea11c91ab594b
Source dataset
uspto-grants-2013_11
Patent number
US08575181B2

Reaction notes

Loading…