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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2036352Generated: October 27, 2026

1,3-Dibromopropane → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-(3-{[2-(tetrahydro-2-furanyl)ethyl]amino}propyl)-9H-purin-6-amine

https://huagongshe.com/reaction/2036352

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DibromopropaneHCID 8001—
Reactant2-(Oxolan-2-yl)ethan-1-amineHCID 4854736—
Reactant2-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purin-6-amineHCID 67211570—
ReactantHCID 178448285HCID 178448285—
Product2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-(3-{[2-(tetrahydro-2-furanyl)ethyl]amino}propyl)-9H-purin-6-amineHCID 67211424—

Reaction Steps

Prepared similarly to Intermediate 15 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,3-dibromopropane, and [2-(tetrahydro-2-furanyl)ethyl]amine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08575181B2
Source datasetuspto-grants-2013_11
ORD IDord-9ef142b239224281885a87ca7acd2073
Source noteuspto-grants-2013_11