1,3-Dibromopropane → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-(3-{[2-(tetrahydro-2-furanyl)ethyl]amino}propyl)-9H-purin-6-amine

HRID 2036352Notes

Reaction equation

HRID 2036352 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23][CH2:22]O2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4].FC(F)(F)[C:30](O)=[O:31].[CH3:35][C@H](OC1NC(N)=C2C(N=1)=NC(OC)=N2)CCC.BrCCCBr.O1CCCC1CCN>>[CH3:35][C@H:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH2:20][CH:24]2[CH2:23][CH2:22][CH2:30][O:31]2)=[C:8]([NH2:27])[N:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 4

HCID 80011,3-DibromopropaneHCID 48547362-(Oxolan-2-yl)ethan-1-amineHCID 672115702-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purin-6-amineHCID 178448285HCID 178448285, compound

Product 1

HCID 672114242-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-(3-{[2-(tetrahydro-2-furanyl)ethyl]amino}propyl)-9H-purin-6-amine

Procedure

Prepared similarly to Intermediate 15 from 2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,3-dibromopropane, and [2-(tetrahydro-2-furanyl)ethyl]amine.

Sources & evidence

ORD record
ord-9ef142b239224281885a87ca7acd2073
Source dataset
uspto-grants-2013_11
Patent number
US08575181B2

Reaction notes

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