1,3-Dibromopropane → N2-Butyl-8-(methyloxy)-9-{3-[(tetrahydro-2-furanylmethyl)amino]propyl}-9H-purine-2,6-diamine
Reaction equation
C(O[C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23][CH2:22][O:21]2)=[C:8]([NH2:27])[N:7]=1)CCC.FC(F)(F)C(O)=O.[CH2:35]([NH:39]C1N=C2C(N=C(OC)N2)=C(N)N=1)[CH2:36][CH2:37][CH3:38].BrCCCBr>>[CH2:35]([NH:39][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23][CH2:22][O:21]2)=[C:8]([NH2:27])[N:7]=1)[CH2:36][CH2:37][CH3:38]Participants
4
Procedure
Prepared similarly to Intermediate 15 from N2-butyl-8-methoxy-9H-purine-2,6-diamine trifluoroacetic acid salt, 1,3-dibromopropane, and 2-(tetrahydro-2H-pyran-4-ylethyl)amine.
Sources & evidence
- ORD record
- ord-26cfae22926d43c38cd1a2404c38ba4b
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08575181B2
Reaction notes
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