Hydrochloric Acid → HCID 67211545, compound

Participants

Reaction Steps

2-(Butyloxy)-8-(methyloxy)-9-{3-[(2R)-tetrahydro-2-furanylamino]propyl}-8,9-dihydro-7H-purin-6-amine (3 mg, 8.23 μmol) was stirred with 4M HCl in 1,4 dioxane (0.05 ml, 0.2 mmol) in methanol (2 ml) at 40° C. for 3 hours. The solvent was stripped using the Radleys blowdown apparatus under a stream of nitrogen. The sample was loaded in methanol and purified by SPE (2 g) on an aminopropyl (NH2) cartridge using methanol. The appropriate fractions were combined and dried under a stream of nitrogen to give the title compound as a white solid (2.8 mg).

Provenance & Evidence