Hydrochloric Acid → HCID 67211545, compound

HRID 2036365Notes

Reaction equation

HRID 2036365 reaction equation
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([NH:10][CH:11]([O:24]C)[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][C@H:19]2[CH2:23][CH2:22][CH2:21][O:20]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].Cl.O1CCOCC1>CO>[NH2:26][C:8]1[N:7]=[C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])[N:14]=[C:13]2[C:9]=1[NH:10][C:11](=[O:24])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][C@H:19]1[CH2:23][CH2:22][CH2:21][O:20]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 67224004HCID 67224004, compound

Product 1

HCID 67211545HCID 67211545, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2-(Butyloxy)-8-(methyloxy)-9-{3-[(2R)-tetrahydro-2-furanylamino]propyl}-8,9-dihydro-7H-purin-6-amine (3 mg, 8.23 μmol) was stirred with 4M HCl in 1,4 dioxane (0.05 ml, 0.2 mmol) in methanol (2 ml) at 40° C. for 3 hours. The solvent was stripped using the Radleys blowdown apparatus under a stream of nitrogen. The sample was loaded in methanol and purified by SPE (2 g) on an aminopropyl (NH2) cartridge using methanol. The appropriate fractions were combined and dried under a stream of nitrogen to give the title compound as a white solid (2.8 mg).

Workup

  1. custompurified by SPE (2 g) on an aminopropyl (NH2) cartridge
  2. customdried under a stream of nitrogen

Sources & evidence

ORD record
ord-6507a4596ad14d42b5c4e5dfa2a7d5bf
Source dataset
uspto-grants-2013_11
Patent number
US08575181B2

Reaction notes

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