反应详情

2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-[5-(tetrahydro-2H-pyran-4-ylamino)pentyl]-9H-purin-6-amine (35.47 mg, 0.084 mmol) was stirred in methanol (2.3 ml) and treated with 4M HCl in 1,4 dioxane (0.527 ml, 2.109 mmol). The reaction was stirred in a capped vial overnight and then evaporated under nitrogen and the residue dissolved in 1:1 DMSO:MeOH (1 ml) and purified by Mass Directed AutoPrep (Method A). Product-containing fractions were combined and evaporated in a nitrogen blowdown unit to give the title compound as an off-white gum (23.28 mg).

1. customevaporated under nitrogen
2. dissolutionthe residue dissolved in 1:1 DMSO
3. customMeOH (1 ml) and purified by Mass Directed AutoPrep (Method A)
4. customevaporated in a nitrogen