HCID 58459354, compound → HCID 58459262, compound

HRID 2036626Notes

Reaction equation

HRID 2036626 reaction equation
O=[C:2]([NH:13][C:14]1[C:19]([NH:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)=[CH:18][CH:17]=[CH:16][N:15]=1)[C@@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4]>CC(O)=O>[N:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[N:20]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[N:13]=[C:2]1[CH:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4]

Participants

3

Reactant 1

HCID 58459354HCID 58459354, compound

Product 1

HCID 58459262HCID 58459262, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of (S)-tert-butyl 1-oxo-1-(3-(pyridin-2-ylamino)pyridin-2-ylamino)-propan-2-ylcarbamate (0.5432 g, 1.520 mmol) in AcOH (5.07 mL) was heated at 100° C. with stirring. After 3 days, the mixture was concentrated in vacuo to provide tert-butyl 1-(1-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridin-2-yl)ethylcarbamate as a brown syrup: LC-MS (ESI) m/z 340.1 [M+H]+. Epimerization occurred. The crude product was used without further purification. 1-(1-(Pyridin-2-yl)-1H-imidazo[4,5-b]pyridin-2-yl)ethanamine

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cca36a0e5eb4490f99cf8048bec7484d
Source dataset
uspto-grants-2013_11
Patent number
US08575183B2

Reaction notes

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