HCID 58459354, compound → HCID 58459262, compound

Participants

Reaction Steps

A solution of (S)-tert-butyl 1-oxo-1-(3-(pyridin-2-ylamino)pyridin-2-ylamino)-propan-2-ylcarbamate (0.5432 g, 1.520 mmol) in AcOH (5.07 mL) was heated at 100° C. with stirring. After 3 days, the mixture was concentrated in vacuo to provide tert-butyl 1-(1-(pyridin-2-yl)-1H-imidazo[4,5-b]pyridin-2-yl)ethylcarbamate as a brown syrup: LC-MS (ESI) m/z 340.1 [M+H]+. Epimerization occurred. The crude product was used without further purification. 1-(1-(Pyridin-2-yl)-1H-imidazo[4,5-b]pyridin-2-yl)ethanamine

Provenance & Evidence